The cooking time for meatloaf at 375 degrees Fahrenheit (190 degrees Celsius) can vary depending on the size and thickness of the meatloaf. As a general guideline, it typically takes around 45 minutes to 1 hour to cook a 2-pound meatloaf at this temperature.
To ensure that the meatloaf is cooked thoroughly, it’s important to use a meat thermometer to check the internal temperature. The temperature should reach 160 degrees Fahrenheit (71 degrees Celsius) in the center of the meatloaf for it to be safe to eat. You can also check if the meatloaf is done by inserting a toothpick or a knife in the center of the meatloaf, and if it comes out clean, the meatloaf is ready.